Molecular Mechanism for the Carnosine-Induced Improvement of Brain Function: Why Carnosine Can Improve Brain Function ?
نویسندگان
چکیده
منابع مشابه
Modulation of mitochondrial function and autophagy mediates carnosine neuroprotection against ischemic brain damage.
BACKGROUND AND PURPOSE Despite the rapidly increasing global burden of ischemic stroke, no therapeutic options for neuroprotection against stroke currently exist. Recent studies have shown that autophagy plays a key role in ischemic neuronal death, and treatments that target autophagy may represent a novel strategy in neuroprotection. We investigated whether autophagy is regulated by carnosine,...
متن کاملEffects of Beta-Alanine Supplementation on Brain Homocarnosine/Carnosine Signal and Cognitive Function: An Exploratory Study
OBJECTIVES Two independent studies were conducted to examine the effects of 28 d of beta-alanine supplementation at 6.4 g d(-1) on brain homocarnosine/carnosine signal in omnivores and vegetarians (Study 1) and on cognitive function before and after exercise in trained cyclists (Study 2). METHODS In Study 1, seven healthy vegetarians (3 women and 4 men) and seven age- and sex-matched omnivore...
متن کاملThe Relationship Between Executive Function and Severe Traumatic Brain Injury
Background: Cognitive impairment is a common complication of Severe Traumatic Brain Injury (STBI). One of cognitive problems following STBI is impaired executive functions which involve high-level cognitive processes and their dysfunction can lead to reduced quality of life. Objective: This study aims to investigate the cognitive impairment in men with STBI compared to healthy men. Materials...
متن کاملProtective effects of carnosine against malondialdehyde-induced toxicity towards cultured rat brain endothelial cells.
Malondialdehyde (MDA) is a deleterious end-product of lipid peroxidation. The naturally-occurring dipeptide carnosine (beta-alanyl-L-histidine) is found in brain and innervated tissues at concentrations up to 20 mM. Recent studies have shown that carnosine can protect proteins against cross-linking mediated by aldehyde-containing sugars and glycolytic intermediates. Here we have investigated wh...
متن کاملCan noninvasive brain stimulation enhance function in the ageing brain?
Advancing age is associated with cognitive and motor performance deficits and a reduced capacity for plasticity. Zimerman and colleagues (Zimerman M, Nitsch M, Giraux P, Gerloff C, Cohen LG, Hummel FC. Ann Neurol 73: 10-15, 2013) have recently shown that noninvasive brain stimulation can enhance behavioral improvements following training on a motor sequence task in older adults. The work is of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: KAGAKU TO SEIBUTSU
سال: 2019
ISSN: 0453-073X,1883-6852
DOI: 10.1271/kagakutoseibutsu.57.596